Supplemental Data (Figures and Tables) from DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma

Abstract

<p>Supplemental Figure 1: The association between deleterious DDR (DNA damage response and repair) alteration status as determined by in silico analysis and (A) Progression-free survival and (B) overall survival, and the association between deleterious DDR alteration status as determined by literature review, and (C) progression-free survival and (D) overall survival. DDRwt: wild type DDR; DDRalt: altered DDR not considered deleterious per methodologies employed. Supplemental Figure 2: Mutation load estimates based on MSK-IMPACT assay recapitulates whole exome sequencing data. Correlation between mutation counts generated from all sequences produced by TGCA bladder cancer whole exome sequencing and counts generated after first subsetting TCGA data to only those reads that coincide with the MSK-IMPACT capture regions. Supplemental Figure 3: (A) Mean number of total mutations, (B) number of copy number alterations and (C) fraction of copy number altered genome based on number of DNA Damage Response and Repair (DDR) alterations. (Whisker plot with Tukey method) Supplemental Figure 4: Influence of total mutation load on (A) Progression-free survival, (B) overall survival and (C) response rate. Total mutation load was divided into quartiles for the purpose of graphical representation. Supplemental Table 1: DDR Gene Panel Supplemental Table 2: All identified DDR alterations</p>