Abstract
Fourteen - twenty-one days after unilateral dorsal root section, interneurones in the deafferented side of the rat spinal cord were more sensitive to iontophoretic application of Eledoisin Related Peptide (ERP - a Substance P analogue). The cells were not more sensitive to all excitatory neurotransmitters as responses to 5-HT were similar on both sides of the cord. The increased responsiveness to ERP was not simply a result of a change in the spontaneous activity of the cells. ERP responsive cells were encountered at similar depths on both sides of the cord and therefore are likely to represent similar populations. It was concluded that supersensitivity, probably of postsynaptic origin, had occurred. These observations provide further support for the postulated role for substance P as a neurotransmitter in primary afferent neurones.
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