Abstract
Summary.Experiments on the cholinesterase activity of homogenates of normal and denervated salivary glands are described.The percentage decrease after various types of denervations was the same as found earlier (Strömblad 1955 b) when the supernatant of the homogenate was estimated.The changes in enzymic activity after denervations were compared with those found when mintakol (or TEPP) was injected into the glands via the secretory duct in amounts causing supersensitivity.It was inferred that the supersensitivity found after denervations could not be wholly due to a decrease in cholinesterase activity. In case of preganglionic denervation it is doubtful if enzyme decrease could play any part in the supersensitivity, while in case of postganglionic parasympathetic denervation it was very suggestive. Experiments are also described which are in accord with a suggestion previously proposed that the difference in sensitivity between a pre‐and postganglionically denervated parotid gland is due to the greater fall in cholinesterase after postganglionic as compared with preganglionic denervation.The supersensitivity caused by excision of the superior cervical ganglion could hardly be attributed to a decrease in cholinesterase activity of the gland.
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