Abstract
Cell mimetic systems like giant unilamellar vesicles (GUVs) encapsulating macromolecules (polyethylene-glycol and dextran) represent an excellent tool to study membrane transformations associated with molecular crowding and protein condensation. Upon liquid-liquid phase separation as in living cells, these GUVs exhibit highly curved structures such as internal nanotubes and the membrane of GUVs form apparent kinks at the contact line of the interface between the two encapsulated aqueous phases. These membrane structures of high curvature have dimensions below conventional optical resolution and if resolved, can provide quantitative information on membrane spontaneous curvature and the intrinsic contact angle describing the wettability difference of the encapsulated phases to the membrane.
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