Abstract
Sentinel lymph node biopsy (SLNB) is a well-established procedure for staging clinically node-negative early breast cancer (BC). Superparamagnetic iron oxide (SPIO) demonstrated efficacy for nodal identification using a magnetic probe after local retroaeroal interstitial injection. Its benefits lie in its flexibility, which is an essential property in the global setting, where access to the isotope is difficult. To the best of our knowledge, this is the first study to evaluate the feasibility and safety of the SPIO for SLNB in BC patients treated with neoadjuvant chemotherapy (NAC). Seventy-four female patients were included. The median time of lymph node retrieval was 20 min. The median number of resected sentinel nodes (SNs) was 4. SN was detected in all patients. No serious adverse event was observed. SPIO in identifying SN in BC patients after NAC is feasible and oncologically safe.
Highlights
Sentinel lymph node biopsy (SLNB) is a well-established procedure for staging clinically node-negative early breast cancer (BC), the optimal surgical management of the axilla has been controversially discussed over the last two decades [1]
This study aimed to evaluate the feasibility and safety of the Superparamagnetic iron oxide (SPIO) for SLNB in BC patients treated with neoadjuvant chemotherapy (NAC)
The study group consisted of female patients only
Summary
Sentinel lymph node biopsy (SLNB) is a well-established procedure for staging clinically node-negative early breast cancer (BC), the optimal surgical management of the axilla has been controversially discussed over the last two decades [1]. Due to its minimally invasive approach and low morbidity, SLNB established a new milestone replacing axillary lymph node dissection (ALND) [2,3]. Sentinel node (SN) detection in BC was introduced by Giuliano in 1994, using blue dye [3]. The simultaneous use of a radioisotope with blue dye increased the SN detection rate up to 96–97%, as shown in the AMAROS and ALMANAC trials [10,11]. The use of a radioactive tracer alone or in combination with blue dye has been recognized as a gold standard of SLNB [4,10]
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