Abstract
Today, magnetic hyperthermia constitutes a complementary way to cancer treatment. This article reports a promising aspect of magnetic hyperthermia addressing superparamagnetic and highly Fe/Au core-shell nanoparticles. Those nanoparticles were prepared using a wet chemical approach at room temperature. We found that the as-synthesized core shells assembled with spherical morphology, including face-centered-cubic Fe cores coated and Au shells. The high-resolution transmission microscope images (HRTEM) revealed the formation of Fe/Au core/shell nanoparticles. The magnetic properties of the samples showed hysteresis loops with coercivity (HC) close to zero, revealing superparamagnetic-like behavior at room temperature. The saturation magnetization (MS) has the value of 165 emu/g for the as-synthesized sample with a Fe:Au ratio of 2:1. We also studied the feasibility of those core-shell particles for magnetic hyperthermia using different frequencies and different applied alternating magnetic fields. The Fe/Au core-shell nanoparticles achieved a specific absorption rate of 50 W/g under applied alternating magnetic field with amplitude 400 Oe and 304 kHz frequency. Based on our findings, the samples can be used as a promising candidate for magnetic hyperthermia for cancer therapy.
Highlights
Magnetic nanoparticle hyperthermia (MNH) treatment is a preferable systematic strategy for cancer therapy compared to radio- or chemotherapy due to its minimized side effects on normal tissues [1,2,3,4,5]
Magnetic nanoparticles can be localized in deep tissues, where alternating magnetic field can move them and lead to heating power which can be used for hyperthermia applications in cancer therapy
For the sample prepared at a 2:1 ratio, the X-ray diffractometry (XRD) peaks confirmed the formation of pure bcc
Summary
The magnetic hyperthermia therapy is based on the fact of the tumor response to heat more than the normal cells and by increasing the temperature of body tissue to more than 42 ◦ C yields selective damage of cancer cells and renders them more sensitive to radiation and anticancer drugs. The feasibility of such magnetic nanoparticle hyperthermia has been obtained using heat mediators of superparamagnetic nanoparticles [1,2,3,4,5]. Magnetic particles are introduced into the tumor tissue and exposed to external AC magnetic fields to increase the tumor temperature above 42 ◦ C
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