Superparamagnetic cobalt nanoparticles in hyperbranched polyester polyol matrix with anti-protease activity

Abstract

A new cobalt nanoparticles (CoNP) with a core–shell structure were obtained in a matrix of a second generation hyperbranched polyester polyol (BH20). The influence of the molar ratio Co2+ to a BH20 on the nature of stabilization centers of cobalt nanoclusters in the polymer morphology magnetic properties anti-protease activity and hemolytic activity of nanoparticles was studied. The obtained nanoparticles are superparamagnetic and have a blocking temperature of 305 K. Inhibition of the activity of the secretory aspartic protease Candida albicans in the presence of nanoparticles is 58–91%. The hemolytic activity of nanoparticles does not exceed 5%. The data obtained determine the presented cobalt nanoparticles in the matrix of the hyperbranched polyester polyol as a promising nanomaterial with low cytotoxicity for use in medicine and pharmacy.