Abstract
We have characterized the effect of angiotensin converting enzyme (ACE) inhibitors on the activity of CuZn-superoxide dismutase (CuZnSOD), Mn-superoxide dismutase (MnSOD), catalase, and selenium-dependent glutathione peroxidase (SeGPx). CF1 mice (4-month-old females) were administered water containing enalapril (20 mg/l) or captopril (50 mg/l), during 4 to 11 weeks. After 11 weeks, enalapril treatment caused an increase in the activity of CuZnSOD, MnSOD and SeGPx, from 19 ± 4 to 46 ± 7, 2.1 ± 0.2 to 3.8 ± 0.2 units/mg protein and 27 ± 3 to 54 ± 3 milliunits/mg protein, respectively. After 11 weeks, captopril treatment increased the activities ( P < 0.05) of CuZnSOD, MnSOD and SeGPx to 35 ± 4, 2.9 ± 0.2 units/mg protein, and 38 ± 2 milliunits/mg protein, respectively. Catalase activity was not affected by the treatments. These results suggest that ACE inhibitors may protect cell components from oxidative damage by increasing the enzymatic antioxidant defenses.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
