Abstract
It has been reported that oxygen-free radicals may be related to inflammation, carcinogenesis, immunity, trauma, ischemia, and aging [1]. The mechanisms of the therapeutic effect of radiation and some chemotherapeutic agents may be also mediated by oxygen-free radicals. Radiosensitivity and the cytotoxicity of chemotherapeutic agents are supposed to be associated with the status of endogenous oxygen-free radical scavengers in tumor tissues. A general characteristic of the tumor cell has been reported to be a diminished amount of superoxide dismutase (SOD) coupled with superoxide radical production [2]. We investigated SOD activity in experimental rat brain tumors and normal rat brains by electron spin resonance spectrometry (ESR) with the spin trapping method.
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