Abstract
Several endogenous cellular constituents were tested tested for their ability to produce superoxide anion (O 2 − from ground-state molecular oxygen upon irradiation by solar radiation. The pyridine cofactors NADPH and NADH, riboflavin, and the nucleosides 2-thiouracil and 4-thiouridine were found to sensitize the transmission of photon energy from solar radiation and monochromatic radiation (290, 334, 365, and 405 nm) to oxygen, resulting in O 2 − formation, as detected by superoxide dismutase-inhibitable cytochrome c reduction. Quantum yields for the production of O 2 − indicate that NADPH is the most efficient and riboflavin the least efficient of the compounds tested. These data indicate that endogenous compounds may participate of O 2 − by solar radiation and imply that O 2 − may play a role in sunlight-induced erythema and dermal carcinogenesis.
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