Abstract
Free radicals, including superoxide, O2−, have been implicated in the pathogenesis of certain types of pulmonary hypertension. Yet, the role of O2− in chronic hypoxia-induced pulmonary hypertension in newborns is unknown. Moreover, there is little information regarding the influence of chronic hypoxia on the expression of O2− enzymatic scavenging systems, such as the cytosolic copper/zinc containing enzyme, superoxide dismutase (SOD)-1 or mitochondrial manganese SOD (SOD-2). Our purpose was to determine whether O2− is involved with the abnormal constrictor responses that develop in resistance pulmonary arteries (RPAs) of newborn pigs exposed to 3 days of hypoxia.
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