Superovulation does not increase embryonic aneuploidy: a prospective evaluation of aneuploidy in natural IVF cycles with comparison to 15,169 embryos from age controlled peers who had superovulation

Abstract

The use of superovulation during IVF provides a greater number of mature oocytes and embryos per cycle and an overall increase in delivery rates when compared with natural cycles. However, some data suggest that superovulation may diminish oocyte quality. Of particular concern are limited animal and human data indicating increasing embryonic aneuploidy with increasing gonadotropin dose. Unfortunately, no data are available which systematically address aneuploidy rates in natural cycles where neither exogenous LH/FSH nor GnRH analogs prior to the mid-cycle surge have been administered.