Abstract
The distribution of exogenously added serotonin between the residue and highspeed supernatant of brain homogenates prepared from normal and drug-pretreated rats was investigated at 0°, 20°, and 37°. The results indicate that the accumulation of exogenous serotonin by particulate fractions of rat brain homogenates was neither temperature dependent nor affected by previous pretreatment of the animals with either reserpine or tranylcypromine. Addition of serotonin up to a thousand times the normal endogenous levels resulted in no apparent saturation of the binding sites. The results strongly suggest that accumulation of exogenous serotonin by residues of brain homogenates is a passive phenomenon. The absence of a saturable component in the residues indicates that uptake of exogenous serotonin at high external concentrations is the result of nonspecific binding.
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