Abstract
Bacterial resistance has become a serious global health issue over the past decades due to the misuse and abuse of antibiotics. The development of effective antibacterial drugs with a new antibacterial mechanism is thus very critical. At present, there are many reports on the antibacterial properties and mechanisms of two-dimensional materials. Currently, the modification of g-C3N4 materials, as widely used two-dimensional materials, has become a key step in extending their potential applications in the field of antimicrobial therapy. In the present work, we prepared sulfur-doped g-C3N4 nanosheets (SCNNSs), which have good water dispersibility and sharp tips. The electrostatic interaction of SCNNSs with Tetrastigma hemsleyanum Diels & Gilg's polysaccharide-3 (THDG-3) provides a new strategy that can improve the killing efficiency of SCNNSs. In addition, THDG-3 can rapidly inhibit bacterial proliferation in the early stage of administration. Combined with the antibacterial activity of the SCNNSs, TPS/SCNNSs can inhibit bacteria for a long time. Scanning electron microscopy (SEM) observation of Escherichia coli (E. coli) after administration of the materials revealed that the bacterial cells were ruptured and their intracellular contents were completely separated from the cell membrane. Therefore, we speculate that the bactericidal mechanism of the TPS/SCNNSs probably involves cell membrane damage. In summary, TPS/SCNNSs achieve fast, long-term, dual-function bacteriostatic properties.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Biological Macromolecules
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.