Abstract
The mechanism of enhancement of growth of partially ultraviolet (UV)-inactivated Newcastle disease virus (NDV) in HeLa cells persistently infected with hemagglutinating virus of Japan (HVJ) (HeLaHvJ) was investigated. HeLaHVJ cells and normal HeLa cells were inoculated with UV-irracliated NDV under similar experimental conditions, and numbers of both infective centers and NDV-antigen producing cells in each culture were counted. It was found that the percentage of HeLaHVJ cells which produced infectious NDV or NDV-antigen during the first cycle of infection was approximately 1.5 times higher than that of normal HeLa cells. Survival curves of UV-irradiated NDV showed that NDV appeared more resistant to UV when titrated in HeLaHVJ cells than in assay in normal HeLa cells. Possible explanations for this phenomenon were discussed
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