Abstract
PurposeTo compare the area of the foveal avascular zone (FAZ) in the superficial and deep retinal layers using two different spectral-domain optical coherence tomography angiography (OCTA) devices.MethodsA cross-sectional comparative study was conducted to obtain macular OCTA images from healthy subjects using Optovue RTVue XR Avanti (Optovue, Inc, Fremont, CA) and Spectralis HRA+OCTA (Heidelberg Engineering, Heidelberg, Germany). Two independent trained graders measured the FAZ area using automated slab segmentation. The FAZ area in the superficial and deep retinal layers were compared.ResultsTwenty-three eyes of 23 subjects were included. The graders agreement was excellent (0.86) for all measurements. The mean FAZ area was significantly larger at the superficial retinal layer as compared to the deep retinal layer on both devices (0.31 0.08 mm vs 0.26 0.08 mm in Optovue and 0.55 0.16 mm vs 0.36 0.13 mm in Spectralis, both P 0.001). The mean FAZ area was significantly greater in the superficial and deep retinal layers using Spectralis as compared to Optovue measurements (P 0.001 for both comparisons).ConclusionIn contrast to previous reports, the FAZ area was larger in the superficial retina as compared to deep retinal layers using updated software versions. Measurements from different devices cannot be used interchangeably.
Highlights
Some retinal pathologies including retinal vascular occlusions and diabetic retinopathy alter Foveal avascular zone (FAZ) shape; FAZ metrics can serve as prognostic biomarkers for visual acuity.[1,2,3,4,5]
The mean FAZ area in the deep retinal layer was significantly greater in the Spectralis as compared to the Optovue images (0.36 ± 0.13 mm2 vs 0.26 ± 0.08 mm2, P
The FAZ measurements were significantly larger in the superficial retina as compared to deep retinal layers, and both measurements were significantly greater using the Spectralis as compared to the Optovue
Summary
Foveal avascular zone (FAZ) is the vessel-free central part of the macula surrounded by a. OCTA is a noninvasive modality to evaluate retinal and choroidal vasculature that generates flow maps of retinal vasculature through discrimination of blood motion signals.[10,11,12,13]
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