Abstract
The article discusses the use of supercritical fluid extraction in the technology for the isolation of resveratrol, a phenolic compound found in Vitis vinifera L. A technology was developed for obtaining the sum of polyphenolic compounds with a quantitative content of resveratrol. As a raw material for the production of the substance, Vitis pomace was used after the production of wine and juice, which makes it possible to introduce complex processing of plant raw materials. For the first time, by the method of carbon dioxide extraction, the conditions for the isolation of resveratrol from Vitis pomace raw materials of the Kazakhstani varieties Saperavi and Cabernet were optimized. The influence of pressure (from 10 to 35 MPa), duration (from 60 to 180 min), temperature (from 50 to 70 °C) was studied when optimizing the extraction mode. The quantitative content of resveratrol in carbon dioxide extracts was determined by high-performance liquid chromatography( HPLC). The optimal parameters for the extraction of Vitis vinifera L. pomace (pressure, duration, temperature) were established, which provide a relatively high content of resveratrol in the extracts.
Highlights
OHResveratrol (1) is a naturally occurring polyphenolic compound whose molecule has the structure of stilbene
The basic structure of resveratrol consists of two phenolic rings linked together by a styrene double bond that forms 3,5,4-trihydroxystilbene
The double bond is responsible for the isometric cis- and trans-forms of resveratrol
Summary
Resveratrol (1) is a naturally occurring polyphenolic compound whose molecule has the structure of stilbene. Resveratrol (1) is isolated from more than 70 plant species, mainly found in all parts of Vitis and products of its processing, in berries, nuts, conifers [1]. Resveratrol (1) has antioxidant, anticarcinogenic, anti-inflammatory, hepatoprotective, neuroprotective, anti-aging and antidiabetic activities [2]. The chemical structure of resveratrol (3,5,4-trihydroxystilbene) was first described by Takaoka, who isolated it from the roots of Veratrum grandiflorum The basic structure of resveratrol consists of two phenolic rings linked together by a styrene double bond that forms 3,5,4-trihydroxystilbene. The double bond is responsible for the isometric cis- and trans-forms of resveratrol
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