Abstract
The use of Freon-22 in supercritical fluid extraction and chromatography was investigated. For the extraction of steroids, the extraction efficiency with supercritical Freon-22 was found to be significantly better than that with supercritical carbon dioxide and the extraction time required was much shorter. Preliminary results for the chromatographic analysis of steroids also indicated that polar compounds could be eluted much more easily with Freon-22 than carbon dioxide as the mobile phase.
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