Supercritical CO₂-Assisted Spray Drying of Strawberry-Like Gold-Coated Magnetite Nanocomposites in Chitosan Powders for Inhalation.

Marta C Silva,Ana Aguiar-Ricardo,Ana Sofia Silva,Javier Fernandez-Lodeiro,Carlos Lodeiro,Teresa Casimiro

doi:10.3390/ma10010074

Abstract

Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD). The dry powder formulations showed adequate morphology and aerodynamic performances (fine particle fraction 48%–55% and aerodynamic diameter of 2.6–2.8 µm) for deep lung deposition through the pulmonary route. Moreover, the release kinetics of IBP was also investigated showing a faster release of the drug at pH 6.8, the pH of lung cancer. POXylated strawberry-like gold-coated magnetite nanocomposites proved to have suitable sizes for cellular internalization and their fluorescent capabilities enable their future use in in vitro cell based assays. As a proof-of-concept, the reported results show that these nano-in-micro formulations could be potential drug vehicles for pulmonary administration.

Highlights

Lung cancer is one of the most common and leading causes of cancer death worldwide [1,2].To address this problem, different systems that can carry active drugs into the site of action and initiate the respective cancer treatments have been widely investigated [3]
As local administration to the lungs has become one of the best alternatives to improve lung cancer outcomes [6], pulmonary delivery has been widely investigated as a primary route of administration, as it enables direct targeting to the lungs for both local and systemic treatment [7]
Magnetic@gold nanocomposites were synthesized were synthesized usingone a layer-by-layer three different layers of two polymers ontodeposition the surfacebyofadding the three different layers two polymers ontomagnetic the surface of the magnetic magnetic core, and of the partial gold was made in situ onto the nanoparticle

Summary

Introduction

Lung cancer is one of the most common and leading causes of cancer death worldwide [1,2]. To address this problem, different systems that can carry active drugs into the site of action and initiate the respective cancer treatments have been widely investigated [3]. As local administration to the lungs has become one of the best alternatives to improve lung cancer outcomes [6], pulmonary delivery has been widely investigated as a primary route of administration, as it enables direct targeting to the lungs for both local and systemic treatment [7].

Methods

Results

Conclusion