Abstract
In yeast the dominant super-suppressorS 5 has a distinct expression in heterozygotes depending on the particular combination of alleles at thead 1 orad 2 loci. If thead 1 combination is represented by two suppressible alleles, the phenotype of diploid is wild. If thead 1 combination consists of a suppressible and a non-suppressible allele the phenotype of the diploid is partially mutant. Such a difference in the manifestation of suppressor depending on the combination of alleles is more pronounced in the case ofad 2 mutations. In the case when bothad 2 alleles are suppressible, the diploid is prototrophic, but when only one allele is suppressible, the diploid is an adenineless auxotroph as a rule. This type ofS 5-effect gave us the possibility to study interallelic complementation atad 2 locus in presence of the super-suppressor. It was shown that some combinations of noncomplementing alleles do complement as a result of suppression. Comparison of the two complementation maps with and without suppressor is made for thead 2 locus. The mechanisms of the phenomena and of super-suppression are discussed.
Published Version
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