Super Resolution Cryo-EM Maps with 3D Deep Generative Networks

Abstract

An increasing number of biological macromolecules have been solved with cryo-Electron Microscopy (cryo-EM). Over the past few years, the resolutions of density maps determined by Cryo-EM have largely improved in general. However, there are still many cases that the resolution is not high enough to model molecular structures with standard computational tools. If the resolution obtained is about the empirical border line (3-4 Å), a small improvement would make structure modeling significant easier.