Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease

Taketoshi Asanuma,Hideaki Enzan,Kei Kubota,Mikinori Kuwabara,Yoshihiro Hayashi,Osamu Inanami,Saburo Onishi,Akira Hirose,Yasuhiro Ogawa,Masafumi Ono,Toshiji Saibara,Jude A Oben

doi:10.1136/gut.2009.176651

Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease

Taketoshi Asanuma, Hideaki Enzan + Show 10 more

https://doi.org/10.1136/gut.2009.176651

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Journal: Gut	Publication Date: Nov 16, 2009
Citations: 79

Affiliation: Hokkaido University, University of Miyazaki, Kochi Medical School Hospital, University College London, St Thomas' Hospital

#Non-alcoholic Fatty Liver Disease #Kupffer Cells + Show 8 more

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Abstract

BackgroundThe pathogenesis of non-alcoholic fatty liver disease (NAFLD) is incompletely understood. Kupffer cells (KCs), phagocytic liver-resident macrophages, provide a protective barrier against egress of endotoxin from the portal to the...

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