Abstract
In this series of papers, we will present the appearance of antibiotics in general, from the original animal and microbial natural peptides and proteins, metabolites of molds and yeasts, and bacterial metabolites, to a new generation of plant-based antibiotics. The focus will be on the discovery of hyperforin and its curative properties as a new multitarget antibiotic with unique properties and possibilities for the development of a multitarget medical tool. Chromatography and mass spectrometry of hyperforin, together with its antibiotic, antiprotozoal, and anticancer activities, will be presented in this series. A description of chromatographic/mass spectrometric evidence of the passage of hyperforin through the blood-testis barrier (BTB) and the blood-brain barrier (BBB) will be provided in part II. This antibiotic is a useful tool in the struggle against Neisseria gonorrhea and Neisseria meningitides because of its free passage through the BTB and BBB and its immunomodulatory effects, together with antibacterial and detoxification effects. This paper is the first in a series that addresses the problems of using antibiotics in general and the need for the development of a new generation of antibiotics. The advantages and disadvantages of using antibiotics in human and veterinary medicine will be discussed, as will the possible associated epidemics in general and the epidemics of methicillin-resistant Staphylococcus aureus (MRSA) in particular.
Highlights
A description of chromatographic/mass spectrometric evidence of the passage of hyperforin through the blood-testis barrier (BTB) and the blood-brain barrier (BBB) will be provided in part II. This antibiotic is a useful tool in the struggle against Neisseria gonorrhea and Neisseria meningitides because of its free passage through the BTB and BBB and its immunomodulatory effects, together with antibacterial and detoxification effects
A political or economic discussion is not the subject of this paper; rather, here we aim to address the following question: “Can modern mass migration be a threat to native populations as an epidemic disaster, and what must be done to avoid this?”
In the “Antibiotikumet “Hyperforin” og andre innholdsstoffer i drogen Hypricum perforatum L.” [9], it was shown that extracts from Hypricum perforatum L. and the substance hyperforin were active against Staphylococcus aureus S.C. (S. aureus subsp. aureus COL, an early methicillin-resistant Staphylococcus aureus), S. aureus 1085, Streptococcus pneumoniae S.P., S. pneumoniae type XVIII, S. viridans, Clostridium sporogenes, Bacillus cereus, Corynebacterium hofmannii, Pseudomonas aeruginosa B10 [17], Proteus mirabilis, and Aspergillus fumigatus
Summary
The development of antibiotics is tightly connected to the discovery and existence of microorganisms and their role as infection agents; in other words, the possibility to detect one-celled organisms under microscopic observation, to cultivate them on fast. I. Brondz 20 media on Petri dishes or in liquid media, to isolate single colonies or individual microorganisms, and to analyze their toxic and useful metabolites. Even before the understanding and acceptance of the germ theory, attempts to use different remedies from natural sources were performed. The struggle against infectious diseases was present when the Miasmic doctrine was accepted as being correct. The appearance of antibiotics provided humankind the possibility to be healthier and live longer; the misunderstanding of the almighty power of antibiotics and the ignorance of some government/health administrators may lead large parts of the general population to disaster and even annihilation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
