Abstract

<p>Sup Figure S1. AsiDNA Structure and Cell survival in response to AsiDNA treatment. (A) AsiDNA structure: AsiDNA is the clinical form of Dbait, a 64-nucleotide (nt) oligodeoxyribonucleotide consisting of two complementary 32-nt strands, connected through a 1,19-bis(phospho)-8-hydraza-2-hydroxy-4-oxa-9-oxo-nonadecane linker, with a cholesterol at the 5Â'-end and three phosphorothioate internucleotide linkages at each of the 5Â' and the 3Â' ends (Agilent, USA). L is an amino linker, X a cholesteryl tetraethyleneglycol, CL a carboxylic (Hydroxyundecanoic) acid Linker and s a phosphorothioate linkage. (B) Cell survival and cell death in response to AsiDNA treatment: Living cells (white) and dead cells (grey) were measured 4 days after treatment by staining with tyrypan blue and counting cells. Results are expressed as the mean of three to four independent experiments. Error bars represent the standard deviation.</p>

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