SUN-471 Nephrotoxic Effect of Gentamicin and Amikacin in Neonatal with Infection

Abstract

Infections and its treatment as a common problem in children may be induce different complications. Ampicillin and Aminoglycosides, as choice drugs for this condition, may be have many important side effects, such as nephrotoxic effect. Therefore, aim of this study was evaluation of nephrotoxic effect of Gentamicin and Amikacin in neonatal with infection. This clinical trial, doubl blind study was conducted on 80 children with aminoglycosides addministration. At the first step, in hospital admission, we have tacken serum and urine sample for diagnosis of infection. Children based on their treatment were divided into two groups, 40 children were treated by ampicillin and amikacin and 40 children were treated by ampicillin and gentamicin, in 7 days period. At the end of treatment period serum and urine samples were taken for measurment of laboratory variables, and GFR, for evaluation of kidney founction. BUN, creatinine and GFR before and after treatment in the two groups not have statistically significant difference in two groups (p > 0.05). In addition age, gender, birth age, infection type, occupation and education of parents and milk type were equal in two groups. Based on our study there are not differences between nephrotoxic effect of gentamicin and amikacin in two groups.