SUN-267 Relationship between Height Velocity and Change of Serum Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Concentrations during Gonadotropin-Releasing Hormone Agonist Treatment in Korean Girls with Idiopathic Central Precocious Puberty

Abstract

Purpose : This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth velocity during treatment in Korean girls with idiopathic central precocious puberty (ICPP). Methods : Data was collected from 97 girls, diagnosed under 9 year of age and treated by GnRHa for at least 1 year between 2014 and 2015. Their body height, weight, ∆ Height standard deviation score (SDS), serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) concentrations and bone age were measured at the start and after a year of GnRHa treatment. Possible correlations between the variables were calculated. Results : During the treatment, height SDS, IGF-1 SDS, IGFBP-3 SDS and IGF-1/IGFBP-3 ratio significantly decreased. There were significant correlations between serum IGF-1 level and ∆ Height SDS (r=0.405, p=0.000), and between serum IGFBP-3 level and ∆ Height SDS (r=0.228, p=0.025). C allele had significant correlation with IGFBP-3 level (p=0.004) but had no significant correlation with ∆ Height SDS (p=0.947). Conclusions : The results suggest that the height velocity during GnRHa treatment may be related to serum IGF-1 and IGFBP-3 concentration thus GnRHa may affect GH-IGF-1 axis.