SUN-200 Pulmonary Function Tests in Hemodialysis Patients and their First-Degree Rlatives as Kidney Donors

Abstract

End-stage kidney disease-ESKD-patients not infrequently develop pulmonary complications such as oedema, infection or pleurisy and eventually need renal replacement therapy(RRT) via dialysis (either hemodialysis or peritoneal dialysis) or kidney transplantation to survive. This prospective study evaluated the pulmonary function tests of patients with chronic kidney disease (CKD) and healthy donors who attended the kidney donor clinic at the Royal Hospital. The study was carried on during the period from Jan ’2010 till Jan “2015. All patients have undergone Pulmonary Functions Test (PFT) at the next day post their hemodialysis session. For statistical analysis, the STATA 12.0 software was used. FVC was 3.67(0.78) and 3.12 (0.82) for control and CKD participants, respectively, p=0.019. FEV1 was 2.97(0.63) 2.57 (0.74) for control and CKD participants, respectively, p=0.043. On the other hand, the FEV1/FVC ratio was 80.5(6.9) and 81.8(0.74) for control and CKD participants, respectively p=0.56. Similarly, there was no significant statistical difference regarding PEF and TLC between CKD and control participants. The VC was 3.78(0 .73) vs 3.38 (0.55), p=0.04 for control and CKD participants, respectively. The ERV values were 1.41 (0.34) and 1.78 (0.48), p=0.01 for control and CKD participants, respectively. But RV and RV/TLC showed no statistically significant difference between control and CKD participants, as shown in table 1. The DLCO was 23.29 (4.77) and 18.16 (4.57), p<0.001, for control and CKD participants, respectively. The VA for control and CKD participants was 4.62 (0.99) and 4.12 (0.84), p=0.06, respectively. DLCO/VA was 5.13 (0.88) and 4.47 (1.0), p=0.01, for control and CKD participants, respectively. The DL/VA adjusted was 5.13(0.17) and 4.46 (1.0), p=0.02, for control and CKD participants, respectively. But, IVC values showed no statistically significant difference between control and CKD participants.Tabled 1ItemPotential Kidney donorCKD -Recipient for KTXP. ValueFVC3.67 SD 0.783.12 SD 0.820.0185FEV12.97 SD 0.632.57 SD 0 .740.0434FEV1/FVC80.48 SD 6.9281.79 SD 9.000.5605PEF416.89 SD 102.89386.92 SD 105.480.3099TLC5.39 SD 2.135.23 SD 2.990.8347VC3.78 SD 0 .733.38 SD 0.550.0424ERV1.41 SD 0.341.78 SD 0.480.0122RV1.61 SD 2.081.95 SD 3.000.6464RV/TLC24.85 SD14.8529.55 SD 16.600.3172DLCO23.29 SD 4.7718.16 SD 4.570.0005DLCO/VA5.13 SD 0.884.47 SD 1.000.0192DL/VA adjusted5.13 SD 0.174.46 SD 1.000.0192VA4.62 SD 0 .994.12 SD 0.840.0695IVC2.14 SD 0.461.98 SD 0.610.3704 Open table in a new tab To the best of our knowledge, this is the first paper to compare pulmonary function tests in hemodialysis patients that being worked up for kidney transplant with their first-degree relatives who were worked up as their kidney donors. The findings of the present study demonstrated that volume overload is closely associated with restrictive and obstructive respiratory abnormalities where respiratory function tests in patients with CKD undergoing dialysis show lower values than those of the general population, and that patients undergoing dialysis have greater impairment of DLCO and FVC than do their first relatives’ kidney transplant donor patients. Uremic pulmonary toxicity is likely to be multifactorial and may differ with different patterns of CKD disease.