SUN-418 CLINICOPATHOLOGICAL FEATURES OF BIOPSY-PROVEN RENAL DISEASES: A SINGLE-CENTER, 10-YEAR RETROSPECTIVE STUDY FROM TURKEY

Abstract

Renal biopsy is a gold standard diagnostic test in patients with renal parenchymal disease. Epidemiology of biopsy-proven renal diseases varies according to the geographic area, socioeconomic condition, race and demography in all over the world. We aimed to analyze the distribution of biopsy-proven renal diseases over a period of 10 years from a tertiary care hospital in Turkey. All the renal biopsies performed from 2007 to 2017 were reviewed retrospectively. Biopsies were evaluated by light microscopy and immunofluorescence microscopy. Data on demographics, comorbidities, serum creatinine concentration, 24 h proteinuria, haematuria, clinical diagnosis, indications of renal biopsy and histological diagnosis were collected. A total of 708 biopsies were analyzed. The results according to gender are presented in Table. The mean patient age was 45± 15 (range 16-80) years. The male:female ratio was 1.2. The most common indication of renal biopsy was nephrotic syndrome (55,1 %). The major histological groups identified were: Primary glomerular diseases (GD) (66.9 %), secondary GD (23.2%), tubulointerstitial diseases (5.2%), and others (5.2%) of the cases. Among primary GD, the most common diagnoses were: Membranous glomerulonephritis (MGN) (24.5 %), focal segmental glomerulosclerosis (FSGS) (23.2%), and IgAnephropathy (19.2%). Secondary GD accounted for 164 (23,2 %) of the cases. The most common secondary GD were secondary amyloidosis (36 %, more frequent in males), lupus nephritis (29.9%, more frequent in females), and diabetic nephropathy (14%). Among the 708 renal biopsy specimens, MGN was the most common cause of PGN and amyloidosis was the most common SGD. Our study provides valuable epidemiological and clinical data on biopsy-proven renal diseases in our country. National registry is needed for better understanding of the epidemiology of renal disease in Turkey.