Abstract
Activation of inflammatory pathways has been implicated as a driver for the development and progression of diabetic kidney disease (DKD). Hyperfiltration (HF) has also been proposed as an early phase of DKD, but the relationship between HF and changes in inflammatory biomarkers remains to be fully defined. In this exploratory study, we aimed to investigate the relationship between diabetic HF in type 1 diabetes (T1DM) and levels of the readily accessible biomarkers, C-reactive protein (CRP) and the Neutrophil to Lymphocyte ratio (NLR), and the novel inflammatory biomarkers sTNFR1/2, serum soluble Interleukin-2 Receptor (IL2R) and soluble receptor for advanced glycation end products (sRAGE). In particular, we have focused on the association between diabetic HF and serum or urinary levels of sTNFR1/2.
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