Abstract
Chronic kidney disease (CKD) accelerates atherogenesis. Reactive aldehydes, including isoprostanes and isolevuglandins (IsoLG) are lipoxidation products carried by high density lipoprotein (HDL). These aldehydes promote cellular dysfunction underlying atherosclerosis and their levels are increased in CKD. We previously used aldehyde scavenger, eg., IsoLG scavenger - salicylamine (SAM) ) to lessen lipoxidation-induced cytotoxicity and now investigate the impact of this treatment on kidney-injury driven acceleration of atherosclerosis.
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