SUN-277 CORRELATION BETWEEN FIBROBLAST GROWTH FACTOR-23 LEVELS AND HAND GRIP STRENGTH AMONG TWICE WEEKLY HEMODIALYSIS PATIENTS

Abstract

Patients with chronic kidney disease (CKD) may have muscular atrophy, low muscle strength and low physical activity. Fibroblast Growth Factor-23 (FGF-23) may involve in bone mineral and muscular dysfunction. Previous studies show an association of FGF-23 with left ventricular hypertrophy, however, there is no studies about whether FGF-23 levels are associated with skeletal muscle strength in hemodialysis patients. Our objective is to determine the correlation between hand-grip strength (HGS) and FGF-23 levels in patients undergoing twice weekly hemodialysis patients. This is a cross-sectional study was conducted on 74 patiens with twice weekly hemodialysis at the Hemodialysis Unit at Rumah Sakit Cipto Mangunkusumo, Jakarta. Before dialysis session, plasma intact FGF-23 levels were measured and hand grip strength was measured by Jamar hydraulic hand dynamometer. Subjects were selected consecutively until the number of subjects met. There were 74 subjects recruited, consisted 7 (18.9%) males and 3 (8.1%) females with average body mass index (BMI) < 18.5 kg/m2. Plasma FGF23 levels were significantly higher in males than in females (3276 pg/ml [ ranging 41to 6613] versus 1585 pg/ml, [ranging 21-4820], respectively). HGS of male patients were lower than females (25 kg [ ranging 11-48] vs 20 kg [ranging 8-26], respectively). After adjusting to Modified Charlson Comorbidity index (mCCI) and BMI, we found a significant correlation between FGF-23 and HGS among female subjects (r = -0.4, p = 0.02) and no significant correlation between FGF-23 and HGS among males (r = -0,053, p = 0.7). In twice weekly hemodialysis patients, FGF-23 has a significant correlation with HGS in females and this was not found in males.