SUN-232 Testosterone Deficiency among Thai Men with Type 2 Diabetes: Prevalence and Associated Factors

Abstract

Objective: The aim of this study is to determine the prevalence and associated factors of hypogonadism among Thai men with type 2 diabetes mellitus (T2DM). Methods: We have conducted a cross-sectional study to determine the prevalence of low testosterone level and its associated factors among 200 Thai men with T2DM who attended at Diabetes Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand between January 2014 and October 2017. The patient characteristics were collected and their symptoms about androgen deficiency, aging male symptoms, erectile dysfunction, and depression and quality of life were evaluated by using Thai version of ADAM, AMS, IIEF-15, PHQ-9 and WHOQOL BREF-THAI questionnaires, respectively. Blood tests for their total testosterone (TT), sex hormone binding globulin (SHBG), free testosterone (cFT) and bioavailable testosterone (cBT) were calculated using Vermeulen’s method were performed. TT < 10 nmol/L, cFT < 0.23 nmol/L or cBT< 5.3 nmol/L were defined as testosterone deficiency. Results: Overall, 11.8 % of men with T2DM had testosterone deficiency (TT < 10 nmol/L). The prevalence of testosterone deficiency was similar among all three criteria. Of noted, 88.2% had secondary hypogonadism and all of them had mild symptoms of androgen deficiency. Waist circumference was significantly positive correlated with testosterone deficiency (OR 1.06, 95%CI) while SHBG levels was significantly negative correlated with testosterone deficiency (OR 0.95, 95% CI). There was no relationship between serum TT level and duration of diabetes, FPG and A1C. Conclusion: Testosterone deficiency among Thai men with T2DM was prevalent. Clinicians should beware of clinical manifestations of hypogonadism to detect and supplement testosterone accordingly.