SUN-216 Association Between Renal Hyperfiltration and Depression in the General Chinese

Abstract

Depression is prevalent in patients with all stages of CKD and is associated with adverse outcome. Abnormally elevated GFR, or hyperfiltration, may play a crucial role in the initiation and progression of CKD. However, the association between hyperfiltration and depression is not known. The aim of this study is to investigate the relationship hyperfiltration and depression. A total of 3716 community volunteers (1303 males and 2413females) aged 40–75 years without CKD from a community in China were included for the study. Depressive symptoms and the presence of a minor or major depressive episode were assessed with the 9-item Patient Health Questionnaire (PHQ-9) and Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)–based structured interview, respectively. The mean age of the participants in the present study was 53.8±9.0 years. 115 participants had clinically relevant depression, and 122 participants had a minor or major depressive episode.In a multivariable logistic regression analysis adjusted for potential confounders, the association between renal hyperfiltration and clinically relevant depression remained significant in men but not in women. As compared with men without renal hyperfiltration, those with renal hyperfiltration had a significant higher risk of clinically relevant depression (PHQ≥10) (OR, 4.75; 95%CI, 1.61–13.98, P=0.005), and a higher risk for a major depressive episode (OR, 7.46; 95%CI, 2.04–27.23, P=0.002). Renal hyperfiltration is associated with depressive symptoms and major depressive episodes in middle-aged and elderly Chinese men without CKD. Future studies are needed to verify and clarify the role of abnormally high eGFR in the development of depression.