Abstract
The histone demethylase Jumonji domain-containing protein 3 (JMJD3) is the enzyme that induces demethylation of histone H3 lysine 27 (H3K27) and its activation is involved in the tumor genesis. Although activation of H3K27 methyltransferase has been shown to be required for renal interstitial fibroblast activation and renal fibrogenesis, the role of JMJD3 in these processes remains elusive.
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