Abstract
Uromodulin, the most abundant protein in urine, is synthesized in the thick ascending loop of Henle. Patients with chronic kidney disease (CKD) have reduced urinary uromodulin levels secondary to tubular damage. Genome wide association studies identified significant single nucleotide polymorphism (SNP) associations with CKD at the uromodulin (UMOD) locus. We examined the association of urinary uromodulin concentrations with CKD and with the SNP rs1333226 in the UMOD gene.
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