SUN-168 Low Serum Adiponectin Levels are Associated with Endothelial Dysfunction in Non-Dialysis Dependent Chronic Kidney Disease Patients

Abstract

Cardiovascular disease, which mainly contributed from atherosclerosis, is the leading cause of death in patients with chronic kidney disease (CKD). Beyond the well-known traditional risk factors, endothelial dysfunction is closely associated with cardiovascular mortality and is highly prevalent in patients with CKD. Moreover, adipose tissue, which secreted various adipokines, was shown to play a critical role in the regulation of endothelial function. We aimed to evaluate the correlation of endothelial function with serum levels of adiponectin and leptin in patients with non-dialysis CKD. A total of 130 non-dialysis CKD patients, aged 65.4 ± 11.9 years, were recruited. Serum adiponectin levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0–1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. Among them, 22 (16.9%) patients had poor VRI, who exhibited an elevated serum BUN (P = 0.037), decreased eGFR (P = 0.047) and serum adiponectin levels (P < 0.001). After multivariate adjustment in linear regression, serum BUN levels (β = -0.176, adjusted R2 change = 0.025; P = 0.021) and adiponectin levels (β = 0.487, adjusted R2 change = 0.256; P < 0.001) were independently associated with VRI values in non-dialysis CKD patients. Serum fasting adiponectin levels were positively associated with VRI values among non-dialysis CKD patients. Further studies are required to elucidate the relationship between endothelial function and adiponectin levels in non-dialysis CKD patients.