SUN-164 ASSOCIATION BETWEEN INTRAVENOUS CONTRAST MEDIA AND NON-RECOVERY FROM DIALYSIS-REQUIRING SEPTIC ACUTE KIDNEY INJURY IN INTENSIVE CARE UNIT PATIENTS: A NATIONWIDE OBSERVATIONAL STUDY

Abstract

Although the concern of the effect of iodinated contrast media on acute kidney injury (AKI) affects physician’s decision on the usage of contrast media with computed tomography (CT), recent reports have questioned the causal relationship between administration of intravenous contrast media and the subsequent AKI, and its causal relationship is still controversial. However, there are no previous reports about whether iodinated-contrast media increase non-renal recovery in critically ill patients who require renal replacement therapy (RRT) early after admission. In this retrospective observational study using the Japanese Diagnosis Procedure Combination inpatient database during a period between July 1, 2011 and March 31, 2017, we identified patients with septic AKI who required continuous renal replacement therapy (CRRT) within 1 day after admission. Patients were divided into those who received computed tomography with intravenous contrast media and those without contrast media. We performed propensity score matching to control potential confounders and analyzed associations between exposure to intravenous contrast media and outcomes, including major adverse kidney events (MAKE) which was defined as death and RRT-dependence at discharge, and duration of RRT. A total of 9,055 patients (3293 with contrast media and 5762 without contrast media) were eligible. Propensity score matching analyses showed MAKE at discharge was not statistically different between the groups with and without contract media (49.6% vs 50.7%, p=0.441). RRT duration was median 5 days and also not significantly different between the groups. Use of intravenous contrast media was not associated with increase in MAKE or RRT duration in patients with septic dialysis-requiring AKI.