Abstract
It has long been recognized that a small animal model susceptible to HIV-1 infection with a functional immune system would be extremely useful in the study of HIV/AIDS pathogenesis and for the evaluation of vaccine and therapeutic strategies to combat this disease. By early 2007, a number of reports on various rodent models capable of being infected by and responding to HIV including some with a humanized immune system were published. The New Humanized Rodent Model Workshop, organized by the Division of AIDS (DAIDS), National Institute Allergy and Infection Diseases (NIAID), NIH, was held on September 24, 2007 at Bethesda for the purpose of bringing together key model developers and potential users. This report provides a synopsis of the presentations that discusses the current status of development and use of rodent models to evaluate the pathogenesis of HIV infection and to assess the efficacy of vaccine and therapeutic strategies including microbicides to prevent and/or treat HIVinfection.
Highlights
Investigation of many aspects of the in vivo behavior of HIV as well as testing of the in vivo efficacy of novel antiHIV therapies and vaccines has been hampered by the restriction of HIV infection to humans and primates [1]
It has long been recognized that a small animal model susceptible to HIV-1 infection with a functional immune system would be extremely useful in the study of HIV/AIDS pathogenesis and for the evaluation of vaccine and therapeutic strategies to combat this disease
By early 2007, a number of reports on various rodent models capable of being infected by and responding to HIV including some with a humanized immune system were published
Summary
Investigation of many aspects of the in vivo behavior of HIV as well as testing of the in vivo efficacy of novel antiHIV therapies and vaccines has been hampered by the restriction of HIV infection to humans and primates [1]. Mice cannot be infected with HIV-1, because sequence differences in mouse homologues of the human proteins required for HIV replication prevent their interaction with essential HIV proteins critical for HIV replication such as Env, Tat [2,3] and Rev [3,4], as well as prevent and potentially limit efficient assembly and budding of virus from the cell membrane. The meeting included a discussion by a panel about the current status of the models, future plans, as well as potential use of the models for addressing critical issues in basic immune response studies, pathogenesis, therapeutics, vaccines and microbicides development. Possible studies What types of studies does your model permit that were not possible previously? Can you expand on categories of studies, for example. therapeutics, vaccines, PrEP, PEP, pathogenesis, immunology studies, prevention, and microbicides
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