Abstract
Summaries for patients. Comparative effectiveness of generic and brand-name statins on patient outcomes.
Highlights
Statins are effective in preventing cardiovascular events, but patients do not fully adhere to them
An 8% reduction in the rate of the clinical outcome was observed among patients in the generic group versus those in the brand-name group (HR, 0.92 [95% CI, 0.86 to 0.99])
Randomized, controlled trials have found that statins reduce the relative risk for major vascular events by 21% for each 1.0-mmol/L (39-mg/dL) reduction in lowdensity lipoprotein (LDL) cholesterol level in patients at low risk for vascular disease [3]
Summary
Study Cohort The study cohort comprised Medicare beneficiaries (aged Ն65 years) who had prescription drug coverage through either a stand-alone Medicare Part D plan or a retiree drug plan administered by CVS Caremark, a large national pharmacy benefits manager. We linked claims for filled prescriptions to diagnostic, health. Original Research Comparative Effectiveness of Generic and Brand-Name Statins care utilization, and demographic data from Medicare Parts A and B files and enrollment files. The cohort included patients who initiated a statin (lovastatin, pravastatin, or simvastatin) between 2006 and 2008 and had continuous Medicare and CVS Caremark eligibility in the 6 months before initiation. We restricted the cohort to patients initiating these drugs because they were the only statins for which generic versions were available in the United States during the study. To maximize the generalizability of this comparative effectiveness study, we did not impose any other exclusion criteria
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