Abstract
EDTA extracts of plaque from tube-fed monkeys receiving sucrose by mouth contained radioactivity bound to macromolecules 6 hr after an intraperitoneal injection of [ 35S] sulphate. The isotope was presumably incorporated in sulphated glycoproteins. Gel chromatography of the extract showed two peaks of high molecular weight material, both absorbing at 215 and 280 nm and both containing radioactivity. Isoelectric focusing indicated a pI of about 3 for the radioactive macromolecules. Autoradiography of the minor salivary glands in the labial mucosa facing the dental plaque showed production of sulphated substances in these glands. It is suggested that sulphated glycoproteins may be important for the adhesion and cohesion of dental plaque because of their physico-chemical properties, and that the acidic agglutination factors described in the literature may contain such substances.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
