Abstract
Sulphasalazine (SASP) and balsalazide (BSZ) inhibited 48/80 or substance P-induced histamine release from rat peritoneal mast cells and rat erythrocyte lysis induced by heat, phospholipase C (PLC) or deoxycholic acid (DA). In thein situ ethanol-perfused rat rectocolon, SASP or BSZ (administered via the colonic lumen) reduced ethanol-induced release of histamine and lactate dehydrogenase (LDH), tissue oedema and myeloperoxidase (MPO) activity. These results suggest that the drugs are membranestabilizing, cytoprotective and anti-inflammatory. The inhibition of rat erythrocyte lysis by SASP and BSZ was reduced more by pre-treatment of the erythrocytes with trinitrobenzene sulphonic acid (TNBS), which denatures proteins, than by PLC or DA, indicating that the cell membrane-stabilizing action of SASP and BSZ may be more related to cell membrane proteins than lipids.
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