Abstract
BackgroundReactive airway dysfunction syndrome (RADS), also called irritant-induced asthma, is a type of occupational asthma that can occur within a very short period of latency. The study sought to investigate the influence of sulfur dioxide (SO2) exposure on CD19+ cells and nasal epithelial injury.MethodsWe investigated the effects of SO2 on CD19 expression and morphological changes of nasal epithelia in rats. In the study, 20 rats were randomly divided into the SO2 exposure group that were exposed to 600 ppm SO2, 2 h/day for consecutive 7 days, and the control group that were exposed to filtered air).ResultsInhalation of high concentration of SO2significantly reduced CD19 expression at both the mRNA transcript and protein levels, and reduced the percentages of CD19+ cells and CD19+/CD23+ cells in the nasal septum. However, inhalation of high concentration of SO2 did not affect immunoglobulin (Ig) G, IgA and IgE levels in the serum and nasal septum. More importantly, SO2 exposure also caused mild structural changes of the nasal septum.ConclusionOur results reveal that inhalation of a high concentration of SO2 reduces CD19 expression and causes structural change of the nasal septum in rats.
Highlights
Reactive airway dysfunction syndrome (RADS), called irritant-induced asthma, is a type of occupational asthma that can occur within a very short period of latency
SO2 exposure decreased the percentage of CD19+ and CD19+/CD23+ cells
SO2 inhalation reduces CD19 expression in the nasal septum The rats were healthy before the experiment
Summary
Reactive airway dysfunction syndrome (RADS), called irritant-induced asthma, is a type of occupational asthma that can occur within a very short period of latency. The study sought to investigate the influence of sulfur dioxide (SO2) exposure on CD19+ cells and nasal epithelial injury. With intensive studies on the pathogenesis of asthma, a deep insight into RADS has been gained [2]. RADS is characterized clinically by asthma-like symptoms including cough, wheezing, chest tightness, Sulfur dioxide (SO2) emissions are mainly produced from industrial processes, including metal extraction from ores, power plants and refineries. Owing to its rotten-egg odour, sulfur dioxide can be noted at levels between 0.3 and 5 ppm (ppm). Exposure to levels as low as 0.1 to 0.5 ppm can cause bronchoconstriction in humans with asthma. The influence of exposure to high concentrations of SO2 for a short time has
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