Abstract
BackgroundThe SULT1A1 Arg213His (rs9282861) polymorphism is reported to be associated with many kinds of cancer risk. However, the findings are conflicting. For better understanding this SNP site and cancer risk, we summarized available data and performed this meta-analysis.MethodsData were collected from the following electronic databases: PubMed, Web of Knowledge and CNKI. The association was assessed by odd ratio (OR) and the corresponding 95% confidence interval (95% CI).ResultsA total of 53 studies including 16733 cancer patients and 23334 controls based on the search criteria were analyzed. Overall, we found SULT1A1 Arg213His polymorphism can increase cancer risk under heterozygous (OR = 1.09, 95% CI = 1.01–1.18, P = 0.040), dominant (OR = 1.10, 95% CI = 1.01–1.19, P = 0.021) and allelic (OR = 1.08, 95% CI = 1.02–1.16, P = 0.015) models. In subgroup analyses, significant associations were observed in upper aero digestive tract (UADT) cancer (heterozygous model: OR = 1.62, 95% CI = 1.11–2.35, P = 0.012; dominant model: OR = 1.63, 95% CI = 1.13–2.35, P = 0.009; allelic model: OR = 1.52, 95% CI = 1.10–2.11, P = 0.012) and Indians (recessive model: OR = 1.93, 95% CI = 1.22–3.07, P = 0.005) subgroups. Hospital based study also showed marginally significant association. In the breast cancer subgroup, ethnicity and publication year revealed by meta-regression analysis and one study found by sensitivity analysis were the main sources of heterogeneity. The association between SULT1A1 Arg213His and breast cancer risk was not significant. No publication bias was detected.ConclusionsThe present meta-analysis suggests that SULT1A1 Arg213His polymorphism plays an important role in carcinogenesis, which may be a genetic factor affecting individual susceptibility to UADT cancer. SULT1A1 Arg213His didn't show any association with breast cancer, but the possible risk in Asian population needs further investigation.
Highlights
Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of a broad range of substrates and play an important role in metabolism of endogenous and exogenous compounds including thyroid and steroid hormones, neurotransmitters, drugs and procarcinogens [1,2]
Included studies should meet the following criteria: (1) evaluating the association between SULT1A1 Arg213His polymorphism and cancer risk; (2) study designed as case-control; (3) sufficient data available to estimate an odd ratio (OR) with its 95% confidence interval
The allele and genotype frequencies of the SULT1A1 Arg213His polymorphism were extracted from 66 articles
Summary
Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of a broad range of substrates and play an important role in metabolism of endogenous and exogenous compounds including thyroid and steroid hormones, neurotransmitters, drugs and procarcinogens [1,2]. There are many isoforms of the SULTs supergene family, each with different amino acid sequence identity and substrate specificity [3]. Previous study indicated that exon 7 of the SULT1A1 gene contained a G to A transition at codon 213 (rs9282861) that causes an Arg to His amino acid substitution [4]. The specific role of SULT1A1 Arg213His polymorphism in carcinogenesis has been investigated in numerous case-control studies, the results have been inconclusive, even conflictive. In order to give a comprehensive and precise result, we performed this meta-analysis study to analyze the association between this polymorphism and cancer risk. The SULT1A1 Arg213His (rs9282861) polymorphism is reported to be associated with many kinds of cancer risk. For better understanding this SNP site and cancer risk, we summarized available data and performed this meta-analysis
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