Abstract
Uterine fibroids are fibrotic tumors of uterus associated with abnormal menstrual bleeding and pelvic pain or pressure. Our recent data showed that Hippo signaling was dysregulated (OFF) in uterine fibroids and influenced by extracellular matrix (ECM) stiffness. When Hippo signaling is ‘OFF’, the downstream effectors, YAP/TAZ, interact with TEAD to induce transcription of genes involved in cell growth and fibrosis. Sulforaphane (SFN) is an organic isothiocyanate abundantly present in cruciferous vegetables with tumor-preventing properties.
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