Abstract
This study aimed to investigate the long-term outcomes of sulfonylurea (SU) use in patients with T2DM and compensated liver cirrhosis. From January 1, 2000, to December 31, 2012, we selected the data of 3781 propensity-score-matched SU users and nonusers from Taiwan's National Health Insurance Research Database. The mean follow-up time for this study was 5.74 years. Cox proportional hazards models with robust sandwich standard error estimates were used to compare the risks of main outcomes between SU users and nonusers. The incidence of mortality during follow-up was 3.24 and 4.09 per 100 person-years for SU users and nonusers, respectively. The adjusted hazard ratios and 95% confidence intervals for all-cause mortality, major cardiovascular events, and decompensated cirrhosis in SU users relative to SU nonusers were 0.79 (0.71-0.88), 0.69 (0.61-0.80), and 0.82 (0.66-1.03), respectively. The SU-associated lower risks of death and cardiovascular events seemed to have a dose-response trend. This population-based cohort study demonstrated that SU use was associated with lower risks of death and major cardiovascular events compared with SU non-use in patients with T2DM and compensated liver cirrhosis. SUs may be useful for glycemic management for patients with liver cirrhosis.
Highlights
Type 2 diabetes mellitus (T2DM) may result from insulin resistance or insufficient insulin secretion, which causes inefficient absorption of ingested carbohydrates by the skeletal muscle or liver, resulting in increased blood glucose levels [1]
A total of 25,742 patients were diagnosed as having T2DM and compensated cirrhosis between January 1, 2000, and December 31, 2012
Glimepiride use seemed to be associated with a lower hazard ratio (HR) of cardiovascular events compared with glibenclamide use, and glipizide/gliclazide use. This nationwide cohort study demonstrated that SU use was associated with lower risks of all-cause mortality and major cardiovascular events compared with SU non-use in patients with T2DM and compensated cirrhosis
Summary
This study aimed to investigate the long-term outcomes of sulfonylurea (SU) use in patients with T2DM and compensated liver cirrhosis
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