Abstract
This work demonstrates sulfonyl group-induced remote C(sp3)-N bond construction using a strategy of merging aryl radical-mediated halogen atom transfer and intramolecularly regioselective hydrogen atom transfer (HAT). A plethora of aliphatic sulfones, sulfonamides, and sulfonates are amenable and undergo regioselective C(sp3)-H amination by utilizing an iron salt at room temperature. This protocol involves iodine atom transfer, a HAT process enabled by an alkyl radical adjacent to a sulfonyl group, and amination mediated by an aryl diazonium salt.
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