SULFONIC ACID FUNCTIONALIZED NANOPOROUS SILICA (SBA-PR-SO3H) AS AN EFFICIENT CATALYST FOR THE ONE-POT SYNTHESIS OF 2H-INDAZOLO[1,2-B]PHTHALAZINE-TRIONES

Abstract

ABSTRACT Sulfonic acid functionalized SBA-15 (SBA-Pr-SO 3 H) with a pore size of 6 nm is an efficient catalyst in the green three-component condensation of phthalhydrazide, dimedone and aldehydes to give 2 H -indazolo[1,2- b ]phthalazine-triones under solvent-free conditions in excellent yields and short reaction times. Keywords: Sulfonic acid functionalized SBA-15; Phthalhydrazide; Dimedone; Nano-reactor; One-pot reaction. 1. INTRODUCTION In recent years, heterogeneous catalysts have gained great importance due to economic and environmental considerations. 1-3 Among the various heterogeneous catalysts, particularly, Santa Barbara Amorphous (SBA-15) is significant mesoporous silica with exclusive and important properties such as thick walls, profusely large surface area, huge pore volume and hydrothermal stability which render it as a promising catalyst for wide applications. 4 mixture was heated at 80 °C under solvent-free condition until the reaction was Moreover, functionalization and modification of SBA-15 could enhance and optimize its catalytic activity.