Abstract
Nav1.7 Summary: Maintaining a specific membrane potential is critical to many cellular functions of mammalian cells. The heart, central and peripheral nervous system, and muscle function all depend on the proper regulation and timing of changes in membrane potential. Voltage gatedsodiumchannelsplayakeyroleintheseprocesses.Todate,ninevoltagegatedsodiumchannels,Nav1.1toNav1.9,havebeen identified, and improper NaV activity can lead to a number of negative health consequences. Nav1.7, for example, has been linked to pain sensation. Loss of function mutations of this ion channel have been documented in humans and linked to congenital insensitivity to painful stimuli. Increased Nav1.7, however, has been associated with increased sensitivity to pain. These observations indicate that Nav1.7 blockade may be a viable method of treating chronic pain. Compounds such as Raxatrigine (CNV1014802), a Nav1.7 blocker that recently completed phase II clinical trials for the treatment of lumbar radiculopathy (sciatica),appeartohavevalidatedthishypothesis.Thepresentdisclosuredescribesaseriesofsulfonamidescapableofmodulating Nav1.7 activity and their use as treatment for pain and pain related disorders.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
