Abstract

With the use of a standard dose of sulfobromophthalein sodium (BSP), the metabolism of this substance was studied in a group of full-term and premature infants (normal, hypoxic, and hyperbilirubinemic). Elevated total BSP and BSP conjugate at birth in normal full-term and premature infants approached normal adult levels toward the end of the third week of life. There was no significant difference between the rate of decrease of total or conjugated BSP in the full-term and premature infant. During the first 20 days of life the decrease in total BSP levels proceeded at a faster rate than the decline in BSP conjugate in both normal groups. The mean concentrations of total BSP and BSP conjugate were higher in infants with hypoxia, hyperbilirubinemia, and hemolytic disease of the newborn than in normal infants, but the difference was not statistically significant.

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