Abstract
Three new carboplatin analogs containing P and S ligands are reported. A new synthesis of the intermediate cis-dichlorobis{tris(hydroxymethyl)phosphine}platinum(II) is described. In vitro tests show damage to bacterial DNA and participation of RecA protein in the repair system. Results from a preliminary study in vivo using Leukemia L 1210° cells on mice BDF 1 show that these compounds are potentially active.
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